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Unlocking naturally occurring patient-derived
neuroprotective therapies

THE CHALLENGE

  • The Current Gap

    Despite advances in the treatment of neurological disease there are no neuroprotective therapies on the market.

  • The Complexity of Discovery

    In patients with neurological disorders, neuroprotective mAbs occur naturally. However, identifying them is a monumental task as these patients can create up to a 1 quintillion unique mAbs.

  • The Rarity of Effective mAbs

    Only 1 in 3 billion randomly cloned mAbs bind to brain tissue.

THE SOLUTION

  • High Success Rate

    An impressive 93% of GenrAb’s first 32 cloned fully human mAbs bind to both mouse and human brain tissue.

  • Beyond Symptom Management

    Our approach aims to prevent disease progression and provide neuroprotection without immunomodulation.

  • Proven Preclinical Efficacy

    Our lead mAb, TGM-010, has consistently demonstrated a reduction in disability in preclinical models.

  • Broad-Spectrum Potential

    Targeting a conserved neurodegenerative pathway, TGM-010 shows promise in treating multiple neurologic disorders.

WHAT WE OFFER

Developing neuroprotective agents

GenrAb is harnessing the power of human immunity to develop therapies that can protect and treat patients with neurological diseases. Developing neuroprotective agents will provide patients with the next generation of treatment that can retard the progression of disease and allow for new approaches to their care.

GenrAb’s proprietary Antibody Gene Signature (AGS) technology has identified >400 potentially therapeutic fully-human mAbs to treat neurological disorders. These antibodies leverage naturally created neuroprotective mechanisms found in individuals experiencing neurodegeneration.

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WHY WE DO IT

Changing the course of neurological disorders

At GenrAb, we’re driven by the need to fill a crucial gap in neurological care.

We leverage our groundbreaking AGS technology to unlock new possibilities in treatment, looking to transform patient care and offer hope where it’s most needed. We do this not just for scientific advancement but to profoundly impact lives. This is our commitment, our passion, and our promise.

Our mission is simple yet profound: to develop neuroprotective therapies that change the course of neurological disorders and create a future where effective neurological care is a reality for all.

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HOW WE DO IT

Unlocking the potential of the human immune system to develop advanced treatments for neurological diseases, providing patients with enhanced protection and innovative care strategies.

Immune-Centric
Drug Discovery

Novel approach to drug discovery that harnesses the power of the human immune system as the source of developing novel therapeutics.

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Neuroprotective
Pipeline

Platform in place for drug development of neuroprotective monoclonal antibodies.

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Lead Candidate
Identified

Lead candidate has demonstrated neuroprotective capabilities.

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